Objectives: The participants from the Center for Cancer Immune Therapy (CCIT) actively participate in the clinical trial and are involved in the biobanking. To the scientific part, CCIT will conduct comprehensive research on T cell epitope identification and T cell biology as well as immune escape mechanisms of MCC.
Expertise relevant to the proposed work: CCIT is a research center focused on development and testing of immunological treatment of cancer. CCIT has a research profile based on equally weighted experimental and clinical projects. The laboratory has extensive experience in characterization of tumor antigens recognized by CD8+ T cells, studies of T cell and DC biology, and biological monitoring of vaccination trials. To the clinical part, more than 150 cancer patients have been vaccinated with dendritic cell based therapeutic vaccinations, and currently 6 clinical trials are active, 5 of which include cell transfer to cancer patients.
Specific role in the project: CCIT will participate in WPs 1, 2, 3 and 5. CCIT will actively participate in the clinical trial and will conduct research on T cell epitope identification and T cell biology, such as activation and functionality studies. The center will lead WP 3. CCIT will be heavily involved in the clinical testing and the subsequent monitoring of immune responses.